Isaac vs Neptune (The Binding of Isaac vs Hyperdimension Neptunia)

My guess is this fight depends on what each character will have access to

If Isaac has op items like brimstone, mega blast, soy milk + rock bottom, and many others, he could just stack his abilities and synergies to win

But Neptune could go beyond her Purple Heart form to become her Purple Heart Next Form, making her much more powerful

The reason I made this match up is because Isaac is on the run after his mother tries to sacrifice him because she thinks god is talking to her

So maybe Isaac could mistake Neptune for the one she had been listening to, but Neptune has no idea what’s going on, thus, engaging a fight

Realistically if these 2 interacted, I think Neptune would just comfort Isaac and they’d be great friends